Lyssin (Hydrophobinum) lyss.

Nerves. Cord. Throat. Sexual organs.

Running water (Canth. Stram.). Heat of sun. Glistening objects. Drafts.

Bending backward. Gentle rubbing.

Spasm. Overacute senses.

Fear. Anger. Rapid speech. Impatience and violent temper. Roams about. Constant spitting; ropy, frothy saliva. Spasm of gullet. Can't urinate unless he hears water run. Sexual excitement. Sensitive womb. Barking cough. Pain in neck. Blueness. Convulsions.

Related: Lac-c. Lach.

Ziemsen suggested Lyssin as a substitute for Hydrophobinum, Encyclopaedia, vol. iii, p 472. The sight or sound of running water or pouring water aggravates all complaints. Lyssophobia; fear of becoming mad. Bluish discoloration of wounds (Lach.). Complaints resulting from abnormal sexual desire (from abstinence, Con.). Mental emotion or mortifying news always makes him worse. Cannot bear heat of sun (Gels., Glon., Lach., Nat.). Convulsions: from dazzling or reflected light from water or mirror (Stram.); from even thinking of fluids of any kind; from slightest touch or current of air. Headache: from bites of dogs, whether rabid or not; chronic, from mental emotion or exertion; < by noise of running water or bright light. Salive; tough, ropy, viscid, frothy in mouth and throat, with constant spitting (Hydr.). Sore throat, constant desire to swallow (Lac. c., Mer.). Difficulty in swallowing, even spasm of oesophagus from swallowing liquids; gagging when swallowing water. Constant desire to urinate on seeing running water (Canth., Sulph.); urine scanty, cloudy, contains sugar. Prolapsus uteri; many cases of years' standing cured. Sensitiveness of vagina, rendering coition painful.

Compare: Bell., Canth., Hyos., Stram., in hydrophobia.

Sight or sound of water; bright dazzling light (Stram.); carriage-riding (Coc. - better from, Nit. ac.).

The running of water aggravates the symptoms; may cause a diarrhœa.

Lyssin-Saliva of Rabid Dog (HYDROPHOBINUM)

Affects principally the nervous system; aching in bones. Complaints from abnormal sexual desire. Convulsions brought on by dazzling light or sight of running water.

Lyssophobia; fear of becoming mad. Emotion and bad news aggravate; also, thinking of fluids. Hypersensitiveness of all senses. Chronic headache. Boring pain in forehead.

Constant spitting; saliva tough, viscid. Sore throat; constant desire to swallow, which is difficult; gagging when swallowing water. Froths at mouth.

Lascivious; priapism, with frequent emissions. No emission during coition. Atrophy of testicles. Complaints from abnormal sexual desire.

Uterine sensitiveness; conscious of womb (Helon). Feels prolapsed. Vagina sensitive, rendering coition painful (Berberis). Uterine displacements.

Voice altered in tone. Breathing held for a time. Spasmodic contraction of respiratory muscles.

Desire for stool on hearing or seeing running water. Profuse, watery stools, with pain in bowels; worse, evening. Constant desire to urinate on seeing running water.

Worse, sight or sound of running water or pouring water, or even thinking of fluids; dazzling or reflected light; heat of sun; stooping.

Compare: Xanthium spinosum-Cockle--(said to be specific for hydrophobia and is recommended for chronic cystitis in women). Canth; Bell; Stram; Lach; Nat mur.

Thirtieth potency.

Ill-humor ; irritable ; inclined to use offensive language, to scold his friends, to heat those near him, and to abuse them.

Heat and redness of the face. The articulation of the jaw feels stiff imagines he cannot open the mouth.

Large quantities of tough saliva in the mouth and throat. Continued spitting. Sensation of constriction of the throat. Sensation of elongation of the palate. Imagines that he cannot swallow any thing. Sensation of a lump in the throat, and desire to swallow.

Aversion to water ; says he is thirsty, but cannot look at the water nor bear it poured out. Swallows very small quantities of warm chocolate.

Discharge of bright red blood from the rectum with burning and stinging as from thorns in the anus. Dysenteric stools with tenesmus ; renewed as soon as he bears ; or sees the water run. Discharge of blood from the rectum during the menses.

Men. The testicles shrink and become softer. Hydrocele. Women. Pressing downwards in the region of the uterus (prolapsus uteri).

Stitches in the heart.

Aversion to water ; cannot drink water ; imagines he cannot swallow it. When he hears the water poured out, or if he hears it run or if he sees it, he becomes very irritable, nervous it causes ; desire for stool, and other ailments.

Natrum muriaticum follows well after Hydrophobin.

Loses consciousness for a moment.
Loss of consciousness sometimes at an early stage, but not generally until a short time before death. --s. b.
Does not see nor hear persons around him. --s. b.
Memory for single words much improved.
Strange sensation in head, with loss of memory.
Does not converse as well as usual, but plays chess better ; more inclined to reflect than talk ; not at all lively.
Thoughts of something terrible going to happen come into his mind against his will ; feels impelled to do reckless things, such as throwing child, which he carries in his arms, through the window, and the like.
Could not get rid of the indescribable tormenting feeling that something terrible was going to happen to him.
Fits of abstraction, takes hold of wrong things, often does not know what he wants, says wrong words which have but a remote similarity of sound.
They appreciate the formidable character of the disease and speak frequently with a remarkable quick and sharp articulation of the impending fatal results. --s. b.
During the tranquil intervals, responded correctly to questions put to him, recognized those around him, and with a presentiment of impending death, begged them to pray for him and not to leave him alone. --s. b.
The majority of patients have no adequate conception of real origin of their malady, and affirm in decided terms that the scar is of no significance whatever and causes them no pain. --s. b.
Most commonly the mental faculties are in a superior state of excitement, shown by quick perception, amazing acuteness of understanding and rapidity with which they answer questions. --s. b.
Is astonished in his dream at the readiness with which he can express himself in elegant Latin.
It seems to her as if two entirely different trains of thought influenced her at the same time.
A certain confusion, unsteadiness, weakness of mind. It is very difficult for him to think, sometimes impossible.
Weary and incapable of mental exertion ; school tasks which before had been a pleasure to her, had to be laid aside.
Range of ideas extremely limited, if left to himself is occupied continuously with the same thing, bringing frequently forward same ideas within a short space of time and always in same manner.
Dulness and stupidity ; at night restlessness.
During convulsions, mental illusions and hallucinations ; in intervals of consciousness mental faculties are retained. --s. b.
Believe that they are reduced to their present wretched condition by the instrumentality of those about them. --s. b.
Imagine that they are being abused, and energetically defend themselves against attacks and insults, which in reality are products of their own fancy. --s. b.
Fancies he is being blow at by several persons, some of whom are not present. --s. b.
Raved about the dog that had bitten her ; imagined it to be near her and fought as if to drive it away. --s. b.
Thinks he is a dog or a bird, and runs up and down, chirping and twittering, until he falls down fainting. --s. b.
They fancy that they see objects, animals and men that are not present. --s. b.
Complains bitterly that a fire has been lighted and that the stove is smoking, although there is no fire ; another continually directed a window to be closed, which was not opened. --s. b.
Strange notions and apprehensions during pregnancy.
Slight fits of delirium occur (in advanced state) ; patients frequently forget their friends and relatives ; delirium attended with constant talking. --s. b.
Some delirium and illusions ; fancied doctors were two young girls who had come in to see her. --s. b.
During night delirium <.
Makes speeches in his delirium ; thinks he is a man of great authority. --s. b.
Insane ideas enter his head ; for instance, to throw a glass of water, which he is carrying in his hand, into some one's face, or to stab his flesh with the knife he is holding, and the like.
His mania takes a gloomy character. --s. b.
Mania spermatica ; stallions.
Inclined to use insulting language, scold his friends, beat and abuse those near him.
Inclination to be rude and abusive, to bite and strike. θ Diarrhœa.
A kind of savageness in his temper.
A strong and uncontrollable impulse to do certain acts ; to spring at and to bite any moving object that came within reach ; dog. --s. b.
Is continually tempted to bite her pillow at night. --s. b.
Deny, with great obstinacy, that they have ever been bitten. --s. b.
Incessant talking during night. --s. b.
Speech labored, short and pathetic. --s. b.
Wrote to doctor : I am waiting with impatience that you give me and my young ones something to eat. --s. b.
After fainting spell he wrote on paper : I am forsaken by all ; even the birds of heaven, they do not look at me, do not feed me if hungry ; I hunger with the young ones and am thirsty with their she ones ; my nest is made out of dirt, not gotten by my own exertions,
but by driving them out of their nests and sitting there with the females and the young. --s. b.
Sang more than usual, but involuntarily ; she did not feel at all happy or cheerful.
Goes about house all day singing, moves with greater alacrity and precision than ordinary.
Sighing : with oppressive breathing ; with pain in heart.
Declares amid violent sobs that she is suffering the torments of hell. --s. b.
Lament with greatest anxiety their inability to relieve thirst which afflicts them, and by various contrivances endeavor eagerly to drink. --s. b.
Had a good cry before going to bed.
Weeps bitterly on account of headache.
Before and after as well as during paroxysms, shrieks or inarticulate sounds expressive of utmost despair. During fits, snapping motions with jaws, of an involuntary and spasmodic character. --s. b.
Quiet patients spit into provided vessels, more excited ones discharge saliva upon all sides. --s. b.
Biting, snapping, with convulsions. --s. b.
Ordered her husband to go away, as she wanted to bite him, and joining act to threat, she bit herself in arm. --s. b.
Pieces of carpet put into kennel for dog to lie upon were torn up until they became heaps of loose wool. --s. b.
Desperate efforts were made to break chain ; dog. --s. b.
Break out of their stables furiously and run or jump over ditches and fences. θ Lyssa of sheep.
He cautioned people around him not to inhale his exhaled air, it was spoiled, stinking like rotten eggs, worse than cholera, and could injure. --s. b.
Does not answer questions.
Disinclination to change position of head ; two distinct trains of thought existing at one time in her mind, the idea that she is unable to move her head (when lying down), with the positive conviction that she has only to make up her mind that she will do it to achieve it.
No afraid of dogs, but dislikes to see them because their sight renews her fear. θ Lyssophobia.
Cannot bear to hear others sing, or eat apples.
Exhilarated, felt as if he had received joyful intelligence.
Occasionally exhilarated, then again morose, both feelings going off very readily upon conversing.
Pain in head makes him very uneasy.
Feels depressed and very weak all day.
Depressed, as if something would happen.
An attack of mental depression and indifference quite strange to him ; feels as if he could do nothing ; if he forces himself he lacks mental power.
To such as had continual apprehension respecting their safety it appeared a shorter time since bite. --s. b.
Feels as if something disagreeable would happen ; when thinking the matter over, the feeling passes off.
He feels as if he had heard unpleasant news, or would soon hear it ; until 4 P. M.
Felt as if she was going to get a fit ; at 11 P. M.
Lyssophobia ; fear of becoming mad.
Feels he cannot physically endure his fears much longer, and shall be compelled to go into an insane asylum. θ Lyssophobia.
Mary M., æt. 17, had been bitten several years previously by a dog, and reading of several cases of hydrophobia as reported in papers, was found in following condition : crouched in corner of a sofa, dark red bloated face, expression of terror in face, eyes glistening, conjunctiva
injected red ; was brought into this condition by endeavoring to take a drink of water, and could not hear water mentioned without a shudder of fear, could not swallow, pulse very high, tongue dry and coated red ; Lyssin 2c one dose ; she was better next day, but had several
slight attacks afterwards, always induced by running of water, but always yielding to remedy ; has not had an attack in nearly a year.
Felt as if she was going to die ; as if she was going to sink away.
She has been unable to sleep a wink for several nights ; is driven from bed by indescribable anxiety ; can but sit and walk, or find momentary peace in prayer. --s. b.
Anxiety of mind : restlessness, with great prostration ; with pain in heart ; with headache ; fear of being alone.
A musician received a bite from a small pet dog in calf of left leg while walking through a dark entry ; the bite was very slight, scarcely wounding skin ; the animal was in a healthy condition and remained so ; a pain in bitten place kept
returning from time to time independently of mind dwelling on it, until finally it grew to a burning which extended through entire body, causing an indescribably strange sensation ; in night trembling, and a tormenting fear that he would have hydrophobia ; was thirsty and drank
water freely ; it was two years after the bite when these and the following symptoms appeared : frequent spitting of saliva all through day, only ceasing awhile after taking strong tea in evening ; disturbed dreams at night ; finally could not partake of food or drink,
and complained of pricking stitches under tongue ; mental excitement now as all his life, affects him badly ; hot vapor relieved burning pain in bite, and Lyssin 2c (Jenichen) improved all symptoms rapidly ; in three weeks he considered himself cured, and started on a journey.
Indecision even in small matters.
Ill humor. θ Headache. θ Diarrhœa.
Fretful, hypochondriac mood in evening.
Feels nervous and irritable.
Very cross, so much so that his children expressed great surprise ; he took offense at veriest trifles, scolded his wife and children, felt wretched, could not concentrate his attention on anything ; sullen, does not wish to see or speak to any one.
After attacks of fury, evinces great regret at his behavior, making earnest apologies, warning those about him not to allow him to bite them. --s. b.
Implacable hatred against owners of dog that bit her, with inclination to utter maledictions which, by reason of her careful bringing up and sobriety of her parents, shock her dreadfully. --s. b.
Hypersensitiveness of all the senses.
Exalted state of smell, taste and touch, with a feeling of anxiety and a fear of being alone.
Everything affects him more powerfully ; also tobacco.
He knew exactly where his nurses, his doctors and acquaintances were, if at any distance from him. --s. b.
On a watch held to scrobiculum he sees the hour and minute hands. --s. b.
He says he can see hands on dial plate of church clock. --s. b.
He could hear what was spoken in next room, and counting coppers in a room below him. --s. b.
He knows every one, and answers questions, also is in mesmeric rapport with his physicians. --s. b.
Linen dipped in sugar water, put on pit of stomach, gives a sweet taste in mouth. --s. b.
Copper, if in his room, makes him restless and full of pains. --s. b.
Felt same rheumatic pain his brother complained of. θ Lyssophobia.
Before every spell of somnambulism he crowed like a cock. Very uneasy ; mental disquietude, with headache.
Driven incessantly about without any definite aim. --s. b.
Restlessness, driving him hither and thither, although weak enough to lie down. Restlessness and anxiety at precordia, frequent change of posture and sighing. --s. b.
Restless, constant bleating in a hoarse voice. θ Lyssa of sheep.
Sometimes he could control inclination to stool by a strong effort of will, but effort caused much nervous irritation. θ Chronic camp diarrhœa.
Showing him a bird, he got frightened and thought it was a mouse. --s. b.
Was much frightened during attack, and began to pray ; her husband had to sit up with her and hold her hand ; did not get entirely over attack until 3 A. M.
She feels as after night watching and great anxiety.
Unusually exhausted.
While reading and thinking, headache.
Worse while reading or writing ; headache ; aching in lower jaw.
Severe headache and noseache upon going to bed, after writing all her symptoms.
Attacks of nervous headache become awful and insupportable if he hears water run out of a hydrant.
Pressing headache, < while reading and thinking.
When he hears water poured out, or if he hears it run, or if he sees it, he becomes very irritable, nervous ; it causes desire for stool and other ailments.
The mere sight of a drinking vessel containing water is intolerable ; they turn away their faces, shriek out loud, beckon anxiously with hands to have the water removed, for voice and breath fail. --s. b.
Mental emotion always makes him worse.
Mortifying news affects him very much.
A certain wildness of humor.
Disposed to get angry ; flying into a passion.
Every offense she feels very much.
Excitability prevents sleep.
Frequent gaping without being sleepy, most when he has to listen to others.
Thinking of fluids of any kind, even of blood, brings on convulsions. --s. b.
The mere idea of drink, fluids, pouring out fluids, may cause a paroxysm. --s. b.
Hyperesthesia, rerophobia, current of air, bright light, sight of any shining object, slightest touch, even conversation in vicinity of patient, may throw him into a most violent agitation and bring on severe convulsions. --s. b.
The mere thought of fluids, of drinking, of swallowing, or offer of anything to drink, is sufficient to bring on convulsions ; the same effect is produced by other sources of irritation, such as a simple breath of air, the attempt to touch the sick, every hurried approach towards
him, the light of shining objects. --s. b.
Even the sight of water, or other fluid, or of anything having the least resemblance to it, such as a looking glass or white substance, whereby an occasion will be given for renewal of idea of their former pain, occasion greatest distress and a return of convulsions. --s. b.
Such as were afflicted with grief from any cause were much sooner affected with the disease. A sudden fright starts convulsions. --s. b.
Nose pains from thinking.
Had no symptoms of disease for four months until after receiving very ill usage. --s. b.
Dread and fear brought on symptoms. --s. b.
Outburst of passion or excesses of any kind hasten the outbreak. --s. b.
Any sudden movement near a rabid dog is a stimulus to inflict the fatal bite. --s. b.

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Description:
Introduced and proved by Hering in 1833, fifty years before the crude experiments of Pasteur with the serum. The toxic or non-toxic property of animal saliva has long been a question of scientific discussion. Trevinarus found that the human saliva became red by the addition of tincture of iron; and Gmelin discovered that this color was caused by Sulpho-cyanate. The question in dispute appeared to be that Cyanic acid being a poison, Sulpho-cyanate also must be one, and or course its combination with alkalies, and being poisons, they could not be in the saliva. Years before this discovery, Oken had declared that "saliva is poison." But the discoveries of Liebig and other chemists have demonstrated that Sulpho-cyanic acid is to be found in sheep, dogs and many other animals.
The experiments of Bernard and others, in Virchow's Archives, 1858, have decided that Sulpho-cyanate of Potash found in saliva of animals, acts as a poison under certain conditions. Bernard considered that it acted only by application to cellular tissue. In this he was, no doubt, in error, being misled by the analogy of the snake poison. But, Weir Mitchell in his "Researches on the Venom of the Rattlesnake," page 34 says, he "could not discover any in the rattlesnake poison, notwithstanding repeated experiments."
Livingstone, the African explorer, has reported the bite of the lion as poisonous; and the same claim is made in the East Indies regarding the bite of the tiger. From time immemorial it has been known in every country village that the bite of an angry cat is poisonous, and the effects often severe, even fatal. This is also true with the bite of all other animals, human beings included, when in a fit of passion.
Hering reports a case taken from a French journal in which a healthy farmer, æt. 19, while holding a duck in his lap was bitten on the lip by the angry drake. The same day he felt sick, grew rapidly worse, and a few weeks after died. He also says, that "after the bite of a dog not rabid difficult healing ulcers will follow." It is further known, that after the bite of a rabid dog not only the wounds made by the teeth heal in an unsually short time, but several physicians have observed that even the usual cauterizations are not inclined to inflame, rather more inclined to heal quickly. We may take this for a pathognomonic symptom of the slumbering poison of Lyssin; the same thing is true of leprosy before it breaks out. Now comes the work of Pasteur, in 1878, 1879 and 1880:
His experiments furnished evidence that the malignant disease, splenic fever, was caused by bacteria.
An animal inoculated with a few drops of a liquid containing this bacteria, develops the disease with astonishing rapidity and dies within one or two day. But, he claims that chickens are an exception to this rule, because when similarly inoculated they remain in perfect health. Pasteur's explanation of this strange fact is based on a higher bodily temperature of birds than any other warm blooded animals. The temperature of animals most readily affected by splenic fever ranges from 33 to 35°C., while the blood temperature of chickens is from 42 to 43°C degrees. Now, by reducing the temperature of the chicken after inoculation, Pasteur found it had died of splenic fever, the same as any other animal. Further experiments by Pasteur convinced him that propagation of bacteria is arrested by a temperature of 44 or more degrees. These facts called Pasteur's attention to radiate heat as the best local application to prevent the generation of bacteria. And the same principle has been applied in domestic practice for the cure of a snakebite by killing a chicken, cutting it open and applying the warm surface to the bitten limb, replacing it as soon as it became cold by another, and in this way it is claimed that on the plains of the West, where the bite of the rattlesnake is so common, that nearly every case has been cured; the 10 degrees of greater heat seemed to be sufficient in the bite of the rattlesnake as well as of the bacteria of splenic fever.
In June, 1831, Hering published a letter in Stapf's Archives, Vol. 10, which was dated June 18th, 1830, in which he says: "The proving of snake poison might pave the way to the prevention of hydrophobia and variola by the proving of their respective morbific poisons." And on page 30, of the same volume, he says: "Same is said of psora."
It will be remembered that Hering's immortal proving of Lachesis was begun in 1828, and experimented with for three years, when it was finally published.
Hence the experience which Hering obtained in the proving of the serpent poison was evidently the inspiration for his suggestion that the proving on the healthy of Lyssin, Variolinum, Psorinum and other nosodes would form valuable remedies in the treatment of many of our obstinate diseases. Hering no sooner became firmly convinced of the truth of his suggestion than he at once set to work to put it into execution.
But, the first thing to do was to find a mad dog. The opportunity occurred on the 27th of August, 1833, when a German baker invited him to come to his house to examine a dog. The following description of his capture of a rabid dog and obtaining the saliva for a proving is taken from a paper by Hering in the North American Journal of 1878 :

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